Suzetrigine: New Pain Relief Without Addiction

As we continue to navigate the thorny world of pain management, a new era is dawning—ushering in treatments that sidestep the suffocating grip of addiction. At the heart of this revolution lies suzetrigine, a game-changing, non-opioid solution that’s been put under the microscope and emerged victorious. The U.S. Food and Drug Administration’s recent nod of approval isn’t just a tip of the hat; it’s a clarion call for change in how we tackle acute pain.

Our society has long been in the throes of an opioid crisis—one that tightens its grasp with every pill prescribed. Yet, as opioid prescriptions dwindle, a fresh fightback is underway, targeting pain at its roots rather than simply dulling it. Enter suzetrigine, a sodium channel blocker that’s rewriting the rules of pain relief. It’s not just about its efficacy, but its freedom from the perilous chains of addiction—a stunning breakthrough that’s been decades in the making.

Unlike its opioid predecessors, suzetrigine is designed to block specific pain signals before they reach and overwhelm the brain. This innovative action promises not only a reduction in pain but a significant shift in how we perceive and manage it. By focusing on sodium channels—namely Nav1.8—this medication targets the very foundation of acute inflammatory and neuropathic pain, heralding a promising leap forward.

The landscape of pain treatment is evolving, pivoting from dependency-inducing prescriptions to precise, non-addictive alternatives. Patients and practitioners alike are gearing up for this new wave, where the potential for safe, effective pain management grows ever brighter. It’s a transformation—long-awaited and much-needed—that could reshape the future of medicine as we know it.

While the cost of suzetrigine, marketed as Journavx, may prompt a nose wrinkle or two compared to its generic counterparts, the list price of $15.50 per pill pales when weighed against the staggering human and economic toll of opioid addiction. With nausea, constipation, and headache being the most common side effects—absent of addiction fears—the promise of this drug echoes louder.

As we stand on this precipice of progress, the future seems vivid with potential. Non-opioid treatments are stepping into the spotlight, offering a robust alternative that sidesteps the abyss of addiction while aiming for the same target—pain relief. It’s a pivotal moment, where science takes the reins, guiding us towards a new paradigm of health and hope.

Bird Flu Alert: Preparing for Next Pandemic

Gearing Up for Future Viral Outbreaks: Lessons from Bird Flu

In the shadows of history’s pandemics, the world stands at a crossroads once more. The recent wave of bird flu outbreaks has not only put flocks under the microscope but serves as a stark reminder of the invisible threads weaving our ecosystems and health together.

Around the globe, H5N1 bird flu strains dance between farms and forests, sparking fears of an airborne transformation that could trigger the next pandemic. Though currently tethered to birds, scientists warn that nature has a knack for surprises—mutations could easily vault the virus across species barriers.

This isn’t just about birds. It’s about grappling with the domino effect—a single viral mutation could set off a cascade across our tightly linked global food supply chains. Picture soaring egg prices and the potential ripple effect; from poultry shortages to economic strain, it paints a sobering scenario.

Experts advocate for a proactive playbook. Iowa’s Governor proposed injecting funds into vaccine research, underscoring the crucial need for rapid development as a bulwark against potential outbreaks. Massachusetts-based Moderna took the reins, stepping up to forge vaccines that may serve as our shield against these microscopic marauders.

The lessons from the ongoing fight against bird flu are crystal clear: we must build an arsenal of knowledge and preparedness. Modern technology offers a path forward, from viral tracking systems to cutting-edge research that maps potential cross-species transmissions.

The call to arms? Enhanced surveillance and swift response plans must be solidified. Let us not be caught unawares—expect the unexpected and equip ourselves with the tools to face it head-on. In a world where borders blur and viruses roam freely, the lines between vigilance and victory grow thinner by the day.

By turning our gaze from reaction to prevention, we not only steer away from future pandemics, we also safeguard the delicate balance of our interconnected ecosystems. After all, in this global dance, we’re all in it together.

Billie Eilish Favors Gothic Nautical-inspired Outfit and Prada Sailor’s Cap for 2025 Grammy Awards

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Billie Eilish looked to menswear inspiration on the red carpet for the 2025 Grammy awards on Sunday in Los Angeles. The singer and songwriter is nominated for seven awards, including for her song “Birds of a Feather,” which is up for Best Pop Solo Performance.

To walk the , Eilish wore Prada. She wore a black sailor’s cap from the brand along with a black nylon pull-over top featuring lacing at the chest. Under the top, she wore a white button-up shirt as well as wide-leg navy trousers. She competed the look with a pair of small wire frame shades and snub-nosed black shoes.

Eilish is known for choosing oversized, boxy and often menswear-inspired silhouettes for red carpets. When she attended the Independent Spirit Awards last year, she wore a boxy look from Valentino. It included a jacket and pant set featuring the brand’s V logo printed throughout.

In 2024, Eilish largely worked with stylist Andrew Mukamal. He dressed her in brands like Chanel, Vaquera, Vivienne Westwood and the printed Valentino. In years prior, she had worked with stylist Samantha Burkhart.

The 67th Grammy Awards, hosted by Trevor Noah at Los Angeles’ Crypto.com Arena, celebrated the best in music while also raising funds for wildfire relief efforts in California and honoring first responders. Beyoncé led the nominations with a record-breaking 11 nods. Other top nominees included Charli XCX, Billie Eilish, Kendrick Lamar, Post Malone, Sabrina Carpenter, Chappell Roan and Taylor Swift.

The Beatles won a Grammy last night, thanks to AI | TechCrunch

The Beatles’ AI-assisted track “Now and Then” won the Grammy for Best Rock Performance on Sunday night, marking the first time that a song of its kind has taken home the award.

No, Paul McCartney did not use AI to create some creepy LennonGPT bot. Instead, he used noise reduction systems to clean up a decades-old, low quality piano demo from his late bandmate. This technology is similar to what video call providers like Zoom, FaceTime, and Google Meet use to block out unwanted background noise and deliver a clearer sound.

The surviving Beatles first tried to fix up on Lennon’s demo in the 90s, but the technology available at the time couldn’t quite extract Lennon’s muffled vocals. In 2022, after learning how the filmmakers behind archival Beatles documentary “Get Back” were using new audio isolation techniques to make poorly recorded demos listenable, they revisited “Now and Then.”

Kanye West Told Bianca Censori to ‘Make a Scene’ Before She Dropped Her Coat at the Grammys

Kanye West and his wife, Bianca Censori, made an unforgettable entrance to the 67th Annual Grammy Awards on Feb. 2, 2025. A clip shows West speaking to Censori on the red carpet before she dropped her coat and bared all, revealing a sheer outfit with nothing to cover her. Here’s what West told Censori before the shocking moment, according to a lip reader.

Kanye West and Bianca Censori made waves at the Grammys before taking off. A clip shows West speaking to Censori on the red carpet in front of photographers. The two faced each other while West appeared to instruct Censori on what she should do. West wore an all-black look with sunglasses while Censori arrived in a black fur coat.

Nicola Hickling, the founder and lead analyst at LipReader, explained what West told Censori before she removed the coat with her back turned to the photographers. “You’re making a scene now,” West told Censori, and Censori nodded. “Make a scene, I’ll say it’ll make so much sense,” West said again, DailyMail.com reports.

“Drop it behind you and then turn; I got you,” West reassured.

“Alright let’s go,” Censori said before dropping the coat. She revealed a completely sheer outfit showing her nude body.

Censori and West left the Grammys not long after the red carpet stunt. It’s unclear at this time if security asked them to leave or if they exited on their own accord.

Another source told Page Six that West and Censori were trying to recreate the 2024 Vultures 1 album cover. The cover shows Censori standing nearly nude with her back facing the camera. West stands beside her and faces the camera while wearing a black outfit and white hockey mask.

Blake Lively and Justin Baldoni’s Trial May Be Moved Up, Judge Warns at 1st Hearing

Lively, 37, and Baldoni, 41, were not expected to attend the Monday earing. The pair — who have both filed lawsuits against each other — are set to go to trial on March 9, 2026, per documents obtained by NBC News. During Monday’s 90-minute session, federal judge Lewis J. Liman noted that the March 2026 trial date could be moved up if the complaints continue to be “litigated in the press,” Deadline reported.

Days before the hearing, Lively and her husband, Ryan Reynolds, allegedly objected to being deposed by Baldoni’s lawyer, Bryan Freedman, per court documents obtained by Us Weekly. Since neither Lively nor Baldoni’s lawyers could agree on the matter, they requested the court to weigh in on Monday. “I don’t think you’re going to be the one who chooses who takes Ms. Lively’s deposition,” Judge Liman told Lively’s lawyers on Monday.

The judge also indicated that Baldoni’s lengthy timeline of events was likely to be stricken from the record. On Saturday, February 1, Baldoni released a website, thelawsuitinfo.com, which includes two PDF files titled “Amended Complaint” and “Timeline of Relevant Events” available to download. However, on Monday, the judge stated, “You can’t just attach a factual narrative” to a complaint.

Lively’s team reacted to the first hearing, telling Us in a statement: “We are pleased with the result of today’s hearing and eager to move forward immediately with discovery in this case. The Court granted our request that all attorneys in the matter actually follow the rule of law and not make any statements that could prejudice a jury. This case deals with serious allegations of sexual harassment and retaliation. We will hold the defendants accountable, and we are confident that once all the evidence is submitted in this matter, Ms. Lively will prevail.”

Baldoni’s lawyers, meanwhile, told Us, “Our clients are devastated and want to move the case along as quickly as possible. We just couldn’t be more pleased with how the case was handled today, how it was managed. We’re going to move as quickly as we possibly can and prove our innocence, in a world where sometimes people judge you before they give you a chance. And we’re going to change that.”

Months after speculation swirled of a rift between the It Ends With Us costars, Lively accused Baldoni of sexual harassment and creating an unsafe work environment on the set of the pair’s film in a lawsuit filed in December 2024. He has denied all allegations.

Baldoni and other plaintiffs went on to sue The New York Times in December 2024, who broke the story. A spokesperson for The New York Times told Us at the time that the outlet is planning to “vigorously defend against the lawsuit.” In January 2025, Baldoni’s studio also filed a separate lawsuit against Lively, Reynolds, 48, and her publicist, Leslie Sloane, seeking $400 million in damages.

Lively’s legal team reacted to the lawsuit, sharing, in part, “Their response to sexual harassment allegations: she wanted it, it’s her fault. Their justification for why this happened to her: look what she was wearing. In short, while the victim focuses on the abuse, the abuser focuses on the victim. The strategy of attacking the woman is desperate, it does not refute the evidence in Ms. Lively’s complaint, and it will fail.”

Amid the legal battle, Baldoni’s lawyer released 10 minutes of footage from the It Ends With Us set in an attempt to prove his side of the story. Lively’s team slammed Baldoni and his team for choosing to drop the footage publicly. Lively and Reynolds went on to file a letter in court seeking a protective order against Baldoni’s lawyer Freedman. Days later, Baldoni’s attorney Kevin Fritz asked the judge to deny the gag order if it was formally requested.

Lively and Reynolds allegedly told a federal judge that they are seeking to dismiss Baldoni’s lawsuit. Us reached out to Baldoni’s rep for comment at the time.

Kelsea Ballerini and Noah Kahan Joke They’re on a “Losing High” at Grammys

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Well, you can’t win them all! Just ask Kelsea Ballerini and Noah Kahan. The stars were nominated for Best Country Duo/Group Performance at the 2025 Grammys, but they did not take home the trophy.

The award was presented ahead of the televised broadcast. Kelsea and Noah were nominated for “Cowboys Cry Too” alongside Brothers Osborne, Dan + Shay, Post Malone Featuring Morgan Wallen, and Beyoncé Featuring Miley Cyrus. Beyoncé and Miley ended up taking home the award for “II Most Wanted.”

Kelsea took to her Instagram story to report live from the event, where she interviewed Noah about the loss. The two laughed as she asked, “Noah, what does it feel like to lose three awards for the same song?” Noah replied, “You actually weirdly start to like it, so I’m a losing high right now, woo hoo!” Kelsea adds, “See you at the Grammys!”

Ahead of the Grammys, Kelsea admitted that she didn’t expect to win, telling SiriusXM, “I don’t win things. I mean, that sounds really…I don’t, and I’m cool with it.” She was looking forward to a date night with her boyfriend Chase Stokes and Noah and his fiancé Brenna Nolan. Kelsea has been nominated five times in her career and Noah has been nominated twice, but neither has won (yet!).

Tune in to see who takes home the rest of the awards tonight on CBS at 8 p.m. EST/7 p.m CST, or stream on Paramount+.

Every Movie To Win the Big 5 at The Oscars, Ranked

Winning Best Picture at the Academy Awards has been sought after by many a movie since the ceremony’s inception nearly 100 years ago. Receiving any of the awards is an enormous honor, though it does seem that a few awards are a bit more coveted than others. There is even a term for them: The Big Five — Best Picture, Best Director, Best Actor, Best Actress, and Best Screenplay (Original or Adapted). There have been many Best Picture winners by now, but only three movies in the Academy’s history have won every category of The Big Five. Interestingly, none has come from an original screenplay, so there can still be a first in such a prestige club as this.

There are some movies that almost won the Big Five, which is one heck of an achievement in itself, but winning all five has proven near impossible. One might think that many cinematic giants that were immediately loved (like The Godfather or Amadeus) would be here, but most haven’t been able to pull it off, which makes the three that did all the more special. What does it take to join such Hollywood royalty? One might reasonably ask, “Are these movies better than The Godfather and Amadeus?” Not necessarily, but they do demonstrate that it takes a lot more than luck. The following three masterpieces are often cited among the most influential works of all time and encompass entirely different genres. Their differences make them pretty difficult to rank, so they’re ordered here based on how difficult it was for each to win its five-jeweled crown.

3 ‘It Happened One Night’ (1934) Directed by Frank Capra

Directed by the master craftsman Frank Capra, It Happened One Night won The Big Five in a pretty strange year for the Academy. Although there were 12 nominees for Best Picture (more than even now), most other categories had only 3 nominations. There was an extra nominee for Best Actress, the mighty Bette Davis, due to a brief period that allowed voters to write in their choice on the ballet, but that still only led to four total. These oddities make a little more sense when you consider that this was only the 7th ceremony ever.

Clark Gable does such iconic work as newspaperman Peter Warne that even Bugs Bunny (yes, the Bugs Bunny) would be inspired by how he casually eats a raw carrot. Claudette Colbert likewise does terrific work as the socialite Ellie Andrews, who tries to go from Florida to New York without being stopped by her father. Screenwriter Robert Riskin won for his witty and optimistic adaptation of the short story “Night Bus” by Samuel Hopkins Adams. With only a few moments that haven’t aged so well (despite being over 90 years old), this beautifully shot film is still one of the greatest romantic comedies of all time.

Your Rating close 10 stars 9 stars 8 stars 7 stars 6 stars 5 stars 4 stars 3 stars 2 stars 1 star Rate Now 0/10 It Happened One Night Release Date February 22, 1934 Where to watch Close WHERE TO WATCH Streaming RENT

Cast Clark Gable, Claudette Colbert, Walter Connolly, Roscoe Karns Runtime 105 Minutes Writers Robert Riskin, Samuel Hopkins Adams Powered by Expand Collapse 2 ‘The Silence of the Lambs’ (1991) Directed by Jonathan Demme Close

Directed by Jonathan Demme, The Silence of the Lambs is the only horror movie to win Best Picture. That alone is a monumental achievement, one that’s even more impressive when you consider there were only five nominees at the 64th Academy Awards. However, it was even less likely for an animated movie to win (Beauty and the Beast, the only animated movie to receive a nomination in the original five-nominee category). Writer Ted Tally based his screenplay on the novel by Thomas Harris and deservedly won an Oscar for it. Demme had to beat a few big names for Best Director, mainly Oliver Stone for JFK and Ridley Scott for Thelma & Louise, but he definitely earned his award, too.

Sir Anthony Hopkins won his first of two Oscars that night for his unforgettable turn as Dr. Hannibal Lecter, which probably surprised no one. Celebrated host Billy Crystal even paid homage to the character by getting rolled onto the stage with the iconic mask. Jodie Foster had stiff competition (including both leads of Thelma & Louise), but her performance was strong enough to rightfully take home the trophy. Along with its enduring impact on the film industry and astounding rewatchability to this day, The Silence of the Lambs is one of the most important Best Picture winners ever. It legitimized the horror genre and proved that a film released in February could maintain momentum for over a year.

1 ‘One Flew Over the Cuckoo’s Nest’ (1975) Directed by Milos Forman

Directed by Milos Forman, One Flew Over the Cuckoo’s Nest is easily among the best movies turning 50 this year. In most other award seasons, its five big wins might not have been such a difficult feat to manage, but the New Hollywood made the ’70s one of America’s strongest decades in cinema. The other movies nominated for Best Picture at the 48th Academy Awards were legends, too: Stanley Kubrick’s beautiful Barry Lyndon, Sidney Lumet’s singular Dog Day Afternoon, Steven Spielberg’s Jaws, and Robert Altman’s Nashville. It wouldn’t be an overstatement to call this collection of movies the single greatest Best Picture lineup of the ’70s and one of the ten best of all time; that’s how strong each of these movies is individually.

Could the competition be any scarier? Yes, for Best Director: take the Best Picture nominees, but replace newcomer Spielberg with Federico Fellini. Luckily, co-writers Lawrence Hauben and Bo Goldman had slightly less to worry about for Best Adapted Screenplay. Jack Nicholson turned in the defining performance of his career to beat the likes of Al Pacino and Walter Matthau, while Louise Fletcher’s stone-cold depiction of Nurse Ratched is the most remembered role in her category. It’s amazing that any movie in the ’70s could win The Big Five, but Cuckoo’s Nest still proves itself worthy of the honor every time you see it.

Your Rating close 10 stars 9 stars 8 stars 7 stars 6 stars 5 stars 4 stars 3 stars 2 stars 1 star Rate Now 0/10 One Flew Over the Cuckoo’s Nest Release Date November 19, 1975 Where to watch Close WHERE TO WATCH RENT BUY

Cast Jack Nicholson, Louise Fletcher, Michael Berryman, Brad Dourif, Christopher Lloyd, Will Sampson, Danny DeVito Runtime 133 minutes Writers Lawrence Hauben, Bo Goldman, Ken Kesey Powered by Expand Collapse

NEXT: ‘The 10 Most Disturbing Best Picture Oscar Winners, Ranked’

Lady Gaga, Chappell Roan Use Grammys To Defend Trans Rights After Trump Attacks

Lady Gaga used the Grammys stage to declare that transgender people are “not invisible” on Sunday after President Donald Trump’s attacks on the community since his inauguration.

“Trans people deserve love. The queer community deserves to be lifted up. Music is love,” said Gaga after winning the Grammy in the Best Pop Duo/Group Performance category for her Bruno Mars collaboration “Die With a Smile.”

Gaga has previously spoken out against Trump’s attacks on the trans community and, in an interview with Elle UK published last week, vowed that LGBTQ+ allies were “not going down without a fight” after the president’s election win.

“We will stick together. It’s going to be hard but I’m up for it. We’re up for it. And I just want everyone to know how deeply they’re loved and not invisible,” Gaga told the magazine.

Chappell Roan, who won Best New Artist among her six nominations, also used the occasion to acknowledge that it’s “brutal” for LGBTQ+ people before focusing her attention on the trans community.

“Trans people have always existed and they will forever exist, and they will never, no matter what happens, take trans joy away,” said Roan in an interview with GLAAD red carpet correspondents Chrishell Stause and Anthony Allen Ramos prior to the show.

The artist — who identifies as lesbian and is seen as a champion of the queer community — added, “I would not be here without trans girls, so just know that pop music is thinking about you and cares about you, and I’m trying my best to stand up for you in every way that I can.”

Karla Sofía Gascón: Emilia Pérez star to stay in Oscars race despite row

She added: “I cannot step down from an Oscar nomination because I have not committed any crime, nor have I harmed anyone.”

Gascón stars opposite Zoe Saldana, who is also in the running for best supporting actress, in the film about a Mexican drug lord who changes gender.

The film leads the way with 13 Oscar nominations.

However, Gascón has since been embroiled in a storm over the old posts, which also touched on subjects including the death of George Floyd and diversity at the Oscars.

The posts from X, largely from 2020 and 2021 when it was known as Twitter, were unearthed by journalist Sarah Hagi, and subsequently reported in Variety.

Gascón subsequently deactivated her account on X and apologised for the posts.

“As someone in a marginalised community, I know this suffering all too well and I am deeply sorry to those I have caused pain,” the actress said in a statement last week via Netflix, which is quoted in the Associated Press.

“All my life I have fought for a better world. I believe light will always triumph over darkness.”

Gascón told CNN she offered her “most sincere apologies to all the people who may have felt offended”.

However, she added: “I am neither racist nor anything that all these people have tried to make others believe I am.”

Gascón said she did not “recognise” some of the posts that have been found, and said she had not been given an opportunity to defend herself.

She also denied writing a derogatory post about Emilia Pérez co-star Selena Gomez.

“It’s not mine, of course, I have never said anything about my colleague, I would never refer to her that way,” Gascón said.

Emilia Pérez is the most-nominated non-English language film of all time. It is a French production set mostly in Mexico and mostly acted in Spanish.

Gascón is nominated for best actress for the film’s lead role, making her the first trans person to be nominated in an acting category (although Elliot Page was nominated for Juno in 2008, before the actor transitioned).

The film has not set Netflix alight so far and has divided opinion among those who have watched it. It has also caused controversy in Mexico, because of its depiction of the country.

Despite this, Oscar voters have given it a resounding seal of approval.

However, film critics have warned that the controversy over Gascón’s tweets may threaten the film’s overall chances at this year’s Academy Awards, which take place overnight Sunday 2 March into Monday 3 March UK time.

BBC News has approached Gascón’s representatives and Netflix for a comment.